sirolimus副作用

In recent years, as kidney transplant technology has become increasingly mature, many uremic patients have received kidney transplants and regained their lives. The main ingredient is sirolimus, and its common name is sirolimus tablets. It is suitable for patients who have received kidney transplants. Pay attention to the adverse reactions of the drug. So, what are the side effects of taking sirolimus?

What are the side effects of taking sirolimus:

Sirolimus side effects include: Hepatotoxicity, including fatal hepatic necrosis due to elevated sirolimus trough concentrations (i.e., above therapeutic levels), has been reported. Poor healing. There have been reports of poor healing after transplant surgery, including fascial dehiscence, incisional hernia, and rupture of anastomotic sites (such as wounds, blood vessels, airways, ureters, biliary tracts, etc.). In other clinical experience, azoospermia has been reported in patients receiving sirolimus, and most patients improved after discontinuing sirolimus. Clostridium difficile enterocolitis has been reported in patients receiving sirolimus.

Sirolimus is suitable for patients undergoing kidney transplantation to prevent organ rejection. It is recommended to be used in combination with cyclosporine and corticosteroids. Take orally, once daily. After an organ transplant, it should be started as early as possible. For new transplant recipients, the loading dose should be taken, which is 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although in clinical trials, a loading dose of 15 mg and a maintenance dose of 5 mg/day were used, the therapeutic benefit of doses above 2 mg is unclear for kidney transplant patients. Concomitant use with cyclosporine and corticosteroids is recommended for patients taking daily sirolimus. Patients taking sirolimus (Rapamune) 2 mg daily had overall better health than those taking sirolimus (Rapamune) 5 mg daily.

The above is an introduction to the side effects, I hope it can help everyone.