2020年雷帕鸣在国内的价格

Rapamin (sirolimus tablets, sirolimus) is suitable for patients undergoing kidney transplantation. It is recommended to be used in combination with cyclosporine and corticosteroids to prevent organ rejection. The mechanism of action is: Rapamin inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits antibody production. In cells, rapamycin binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian rapamycin BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from G1 to S phase in the cell cycle.

Rapamin (sirolimus tablets, sirolimus) was launched in China in 2003. What is the price of Rapamin in China in 2020?

Although Rapamin is on the market in China, the price of Rapamin varies in different regions. Patients can consult local pharmacies and hospitals to inquire about the price.

Rapamin and FK506 are structural homologs. Rapamin blocks signal transduction through different cytokine receptors, blocking the progression of T lymphocytes and other cells from the GI phase to the S phase. Compared with FK506, rapamin can block the calcium-dependent and calcium-independent signaling pathways P1 of T lymphocytes and B lymphocytes. Rapamin inhibits the body's immune function by affecting unique cell signaling pathways. On the one hand, rapamycin affects protein synthesis by inhibiting the activation of 70-KSU6 kinase (p7), so that the ribosome 40S subunit S6 protein cannot phosphorylate g7, affecting protein synthesis; on the other hand, by inhibiting the expression of cyclin D2, D3 and cell cycle-dependent kinases, namely cdk4 and cdk6, and the activation of the Cyclin E-cdk2 complex, the cells are arrested in the middle and late stages of GI and cannot continue to proliferate.