雷帕鸣一盒价格多少钱呢？

Rapamune (sirolimus) is sold by Pfizer under the trade name Rapamune. It was originally used as a low-toxic antifungal drug for patients receiving kidney transplants to prevent organ rejection. Used in combination with cyclosporine and corticosteroids.

It was discovered in 1977 that it has immunosuppressive effects (inhibiting mTOR). In September 1999, it was approved by the US FDA to prevent organ transplant rejection. On May 28, 2015, it was approved to treat a rare lung disease, lymphangioleiomyomatosis (LAM).

How much does a box of Rapa Ming cost?

According to the medical companion brigade, Lei Paming was born around 1800. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

Rapamin (sirolimus) inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

Rapamin (sirolimus) oral solution is rapidly absorbed after taking it, with the average peak time after a single oral dose being approximately 1 hour; in kidney transplant recipients, the average peak time after multiple oral doses is approximately 2 hours. High-fat meals can increase the absorption of sirolimus, so it is recommended that oral rapamycin should be taken regularly with or without food. Rapamin is extensively bound to human plasma proteins (approximately 92%). Rapamin is a substrate of cytochrome P450 III A (CYP3A) and P-glycoprotein (P-gp).