雷帕鸣进医保没？

Rapamin is suitable for patients undergoing kidney transplantation. It is recommended to be used in combination with cyclosporine and corticosteroids to prevent organ rejection. Sirolimus (sirolimus tablets) was launched in China in 2003. Has Sirolimus been included in medical insurance?

It is understood that Leipanming has entered the National Medical Insurance Catalog (Category B) and is a medical insurance drug. However, the reimbursement ratios vary from place to place. Patients are advised to consult the local medical insurance bureau.

According to Medical Companion Travel, we have learned that Leipaming, which is currently on the market abroad, is currently the most cost-effective model, with a price of about 1,800. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

The mechanism of action of rapamycin is: Sirolimus inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

Concomitant use with cyclosporine and corticosteroids is recommended. Take orally, once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. In clinical trials, the loading dose of 15 mg and the maintenance dose of 5 mg/day were safe and effective, but for kidney transplant patients, the therapeutic benefits of doses above 2 mg are unclear. The overall safety profile of patients taking rapamycin (sirolimus) 2 mg daily is better than that of patients taking rapamin 5 mg daily.