雷帕鸣的用法用量

Rapamin (sirolimus tablets, sirolimus) is suitable for patients undergoing kidney transplantation. It was launched in China in 2003. The usage and dosage of rapamin is also the most frequently asked question by patients.

The following is the usage and dosage of Leipanming compiled by Medical Companion Travel:

Rapamin (sirolimus tablets, sirolimus) is administered orally once a day. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients. The overall safety profile of patients taking 2 mg of Rapamune daily was better than that of patients taking 5 mg Rapamune daily.

To minimize differences in the proper absorption of sirolimus, the drug should be taken regularly with or without food. Grapefruit juice slows down the metabolism of rapamin, which is regulated by CYP3A4, and should not be used to deliver or dilute rapamin. It is recommended to take rapamycin (sirolimus tablets, sirolimus) 4 hours after taking cyclosporine oral solution (improved type) (such as Neoral oral solution, SangCya oral solution) and/or cyclosporine capsules (improved type).

The average Cmax and AUC of rapamycin (sirolimus) were not significantly affected when taken at the same time or 4 hours after taking cyclosporine. However, within 6 months after kidney transplantation, the patient took multiple doses of rapamycin (4 hours after taking cyclosporine). The oral drug clearance rate of cyclosporine decreased, and a smaller dose of cyclosporine (Neoral) was needed to maintain the target concentration of cyclosporine.