雷帕鸣在中国哪里有卖？

Where can Leipaming be sold in China? It is understood that rapamin (sirolimus tablets, sirolimus) was approved for marketing in China in 2003. Patients can go to pharmacies or hospitals to buy it, but rapamin is a prescription drug, so it requires a prescription from a doctor.

In addition to rapamin (sirolimus tablets, sirolimus) that is available domestically, rapamin (sirolimus tablets, sirolimus) is also available abroad, and the price is relatively cheap. The price of rapamin is about 1,800. Since the exchange rate fluctuates and the price is not fixed, please consult the medical companion passenger service for specific price information.

Rapamin (sirolimus) is a nitrogen-containing macrolide microbial metabolite. They have a special structural group, that is, the lactone ring contains 1 molecule of non-protein amino acid - pipecolic acid. Through the pipecoyl group, it interacts with FKBPs, a type of intracellular immunoaffinity protein with prolyl cis-trans isomerase activity to form a complex. It acts on different targets in cells and exerts a variety of different biological functions.

In 1989, Morris officially began to study rapamycin as a new highly effective immunosuppressant for anti-rejection of organ transplantation. The effective anti-proliferative effect on peripheral blood mononuclear cells was found to be 50 to 500 times stronger than that of cyclosporine CA. Less nephrotoxic than cyclosporine and tacrolimus. Used in combination with cyclosporine to produce a synergistic effect. Although rapamin (sirolimus) is structurally homologous to TRL (Tacmlimus, FK506) and binds to the same immune binding protein, their mechanisms of action are different. SRL inhibits the activity and proliferation of T cells and also inhibits the production of antibodies. In cells, SRL combines with the immunosuppressive protein FKBP 12 to produce an immunosuppressive complex.