雷帕鸣2020年价格

Rapamycin, formerly known as rapamycin (RPM), is a lipophilic triene nitrogen-containing macrolide antibiotic immunosuppressive drug produced by Streptomyces hygroscopicus isolated from soil samples of Easier Island in the Pacific in 1975 by Vezina and others at Ayerst Laboratory in Canada. Rapamin and FK506 share the same receptor in the body, namely FK506 immunobinding protein (FKBP). After rapamin (sirolimus tablets, sirolimus) binds to FKBP, on the one hand, it inhibits the activation of 70-KSU6 kinase (p7), so that the ribosomal 40S subunit S6 protein cannot phosphorylate g7, affecting protein synthesis; on the other hand, it affects protein synthesis by inhibiting Cyclin D2, D3. The expression of cell cycle-dependent kinases, namely cdk4 and cdk6, and the activation of Cyclin E-cdk2 complex make cells stagnant in the middle and late stages of GI and unable to continue to proliferate.

What is the price of Lei Pa Ming in 2020?

According to the Medical Companion Brigade, sirolimus (sirolimus) is available around 1800. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

Studies in experimental models have shown that sirolimus prolongs the survival of allografts (kidney, heart, skin, pancreatic islets, small intestine, pancreatoduodenum, and bone marrow) in mice, rats, pigs, and/or primates. Sirolimus reverses acute rejection of heart and kidney allografts in rats and prolongs transplant survival in presensitized rats. In some studies, the immunosuppressive effects of sirolimus persisted for up to 6 months after stopping treatment. This immune tolerance effect is alloantigen specific.