再障贫血能吃雷帕鸣吗?

Each drug is used by different people in clinical practice, and there are tens of thousands of drugs in clinical practice. This requires patients to understand the relevant information before taking the medication, and it can also help us use the medication correctly. So let’s take a look at which patients can take it.

Rapamin (sirolimus) indications: Suitable for patients undergoing kidney transplantation to prevent organ rejection. It is recommended to be used in combination with cyclosporine and corticosteroids. Concomitant use with cyclosporine and corticosteroids is recommended.

Rapamin (sirolimus) is taken by mouth once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose should be taken, which is 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are satisfactory, the therapeutic benefit of doses above 2 mg is unclear for kidney transplant patients. Daily administration of rapamin is recommended in combination with cyclosporine and corticosteroids. Patients taking rapamycin (sirolimus) 2 mg daily had overall better health than those taking rapamin (sirolimus) 5 mg daily.

Sirolimus (sirolimus) inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

The vast majority of patients must take correct medication based on their actual disease conditions, because drugs are relatively special and cannot be used casually. Whether patients with aplastic anemia can use it still needs to follow the doctor's advice.