雷帕鸣哪里可以买的到

(sirolimus) is a new type of anti-lymphocyte drug mTOR inhibitor. As a new generation of immunosuppressant, its outstanding feature is that it has little nephrotoxicity. Since the drug is mainly metabolized in the liver and gastrointestinal tract through the cytochrome P450 system, more than 91% of the metabolites pass through the gastrointestinal tract, and about 2% are excreted through the skin, so its nephrotoxicity is minimal.

Rapamin's unique mode of immunosuppression is that it blocks the late-stage proliferation response of T lymphocyte activation, inhibits cells from entering the S phase from the G1 phase, blocks the binding of interleukin-2 (IL-2) to its receptors, and prevents Tc and Td cells from becoming sensitized T lymphocytes with immune response and exerting their immune effects.

Through its unique immune mechanism, rapamin can often produce synergistic effects when used in combination with other immunosuppressants, and has the dual purpose of reducing its toxicity and improving efficacy. Rapamin inhibits the activity of mTOR enzyme and has an inhibitory effect on the proliferation of T cells, B cells, mast cells, smooth muscle cells and fibroblasts. At the same time, by inhibiting PDGF, B-FGF, TGF-B and other cytokines, it reduces vasoconstriction and interstitial fibrosis, thereby slowing down the pathological changes of the kidney and improving the patient's renal function.

At present, laboratory studies and clinical observations show that while rapamycin produces immunosuppression, it also has anti-proliferative and anti-tumor effects. Therefore, in patients with CAN or combined tumors after kidney transplantation, the drug has become a good alternative to withdrawing CNI-based regimens.

So, where can I buy such effective Rapamin?

At present, the drug has been launched in China and has been included in the national medical insurance catalog. It is a Class B drug and can be purchased by patients at major hospitals and pharmacies in the country. In addition, patients can also obtain more cost-effective (sirolimus tablets) from some professional overseas medical service institutions in China, such as Medical Companion Travel.

Recommended hot articles: /newsDetail/72835.html