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(sirolimus) Compared with Tac, patients using this drug after kidney transplantation can significantly reduce their own infection rate, suggesting that this drug is safer to use after kidney transplantation. In order to obtain better therapeutic effects, how should patients take Rapamin?

Because sirolimus (i.e., rapamin) is intended for use only by physicians experienced in immunosuppressive therapy and in the management of kidney transplant patients, patients receiving this drug should be treated in an institution with appropriate laboratory and ancillary medical facilities and personnel.

Clinical recommendations include the use of sirolimus in combination with cyclosporine and corticosteroids. This medicine is taken orally, once a day, regularly with or without food. Bioavailability based on crushed, chewed, or cut tablets has not been established, so patients are advised not to use such methods while taking the drug.

Patients who have received a transplant should start taking sirolimus as soon as possible. For de novo kidney transplant recipients, sirolimus is recommended in combination with cyclosporine and corticosteroids. A loading dose of sirolimus should be taken for the first time, which is 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. To maintain sirolimus plasma concentrations within the target range, sirolimus plasma concentrations should be monitored. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the efficacy benefits of doses above 2 mg are unclear for kidney transplant patients. The overall safety profile of patients taking sirolimus oral solution 2 mg daily was better than that of patients taking sirolimus oral solution 5 mg daily.

During treatment, the dosage can be adjusted appropriately for different patients. Once adverse reactions occur during this period, targeted measures should be taken immediately to mitigate them to prevent more serious adverse events from occurring and endangering the health and life safety of patients.

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