西罗莫司片列入医保了吗？

(Lei Pa Ming) Is it included in the medical insurance? Sirolimus tablets (rapamin) are suitable for patients undergoing kidney transplantation. It is recommended to be used in combination with cyclosporine and corticosteroids to prevent organ rejection. In 2003, sirolimus tablets (Repamin) were launched in the country. It is understood that sirolimus tablets (Repamin) have been included in the National Medical Insurance Catalog (Category B) and are medical insurance drugs. However, the reimbursement ratios vary from place to place. It is recommended that patients consult the local medical insurance bureau.

According to Medical Companion Travel, we learned that sirolimus tablets (Repamin) currently on the market abroad are currently the most cost-effective, with a price of about 1,800. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

The mechanism of action of sirolimus tablets (rapamin) is: sirolimus tablets (rapamin) inhibit the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

Concomitant use with cyclosporine and corticosteroids is recommended. Take orally, once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. In clinical trials, the loading dose of 15 mg and the maintenance dose of 5 mg/day were safe and effective, but for kidney transplant patients, the therapeutic benefits of doses above 2 mg are unclear. The overall safety profile of patients taking 2 mg of sirolimus tablets (rapamin) daily is better than that of patients taking 5 mg (rapamin) daily.

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