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How many sirolimus tablets are in a box? Sirolimus produced by Biocon Pharmaceuticals in India is 1mg in a box of 10 tablets.

Sirolimus tablets (rapamin) inhibit the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex.

The main functions of rapamin (sirolimus tablets) are: suitable for patients receiving kidney transplants to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids.

To clinically explore the clinical efficacy and safety of sirolimus in renal transplantation. Start taking rapamycin within 48 hours after organ transplantation, with a loading dose of 6 mg and a maintenance dose of 2 mg. In the experiment, a total of 23 patients with cadaveric kidney transplantation were given triple immunosuppressive therapy of rapamycin (sirolimus) combined with cyclosporine and glucocorticoids. Results: 22 patients completed 6-12 months of follow-up. The incidence rates of acute rejection (AR) at 6 and 12 months were 13.6% (3 cases/22 cases) and 15.8% (3 cases/19 cases) respectively. AR patients were reversed after methylprednisolone pulse treatment and continued to be followed up for more than half a year. No recurrence of AR was found. The adverse reaction of taking rapamycin (sirolimus tablets) was hyperlipidemia (56.5%, 13 cases/23 cases). After reducing the dosage or applying lipid-lowering drugs, the patient's blood lipids dropped to normal or slightly higher than normal levels. Graft vascular disease and cardiovascular complications have not increased so far during follow-up.

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