西罗莫司片的用途和价格

Sirolimus inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukin [IL]-2, IL-4, and IL-15). This mechanism of action is completely different from other immunosuppressants. Sirolimus also inhibits antibody production. In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate an immunosuppressive complex. This sirolimus FKBP-12 complex has no effect on calcineurin activity. This complex binds to the mammalian sirolimus target molecule (mTOR, a key regulatory kinase) and inhibits its activity. This inhibition blocks cytokine-driven T cell proliferation, that is, inhibits the progression from the G1 phase to the S phase of the cell cycle.

Usage of sirolimus tablets: Sirolimus is a new type of highly effective immunosuppressant, which is clinically used for the anti-rejection reaction of organ transplantation and the treatment of autoimmune diseases to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids.

In September 1999, it was approved by the US FDA to prevent organ transplant rejection and was launched in China in 2003. Rapamin (sirolimus tablets, sirolimus) is taken orally, once a day. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose of rapamin should be taken for the first time, that is, 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day.

Price of sirolimus tablets: Rapamin () produced by Biocon Pharmaceutical Factory in India is 1 mg x 10 tablets, and a box sells for about $180. Since exchange rates fluctuate and prices are not fixed, please consult Medical Travel for specific prices.

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