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Is Biocon India effective?

Biocon India, one of India's top three biotech companies, is an emerging global biopharmaceutical company that is committed to reducing the cost of treatment for chronic diseases such as diabetes, cancer and partners to provide affordable healthcare solutions by leveraging India's cost advantages and autoimmune disease patients and healthcare systems around the world.

Rapamune is suitable for patients aged 13 or above who have received kidney transplants to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids. For patients who receive a kidney transplant, rejection after surgery is what everyone is most worried about. This may mean that the surgical treatment fails and the patient cannot survive long-term. The use of Rapamin can effectively reduce the failure rate after transplantation.

Experimental studies have found that Rapamune does not inhibit calcineurin after binding to cytoplasmic proteins, so it can completely avoid the nephrotoxicity of calcineurin inhibitors (CNI). It is one of the best choices when liver or renal insufficiency occurs after organ transplantation or when CNI cannot reach the ideal drug concentration.

Rapamune should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of Rapamune of 15 mg and the maintenance dose of 5 mg/day were safe and effective in clinical trials, the therapeutic benefits of doses above 2 mg are not yet clear for kidney transplant patients. The overall safety profile of patients taking Rapamune 2mg daily is better than that of patients taking Rapamune 5mg daily.

It should be noted that grapefruit juice can slow down the metabolism of Rapamune, which is regulated by CYP3A4, and therefore should not be used to deliver or dilute Rapamune.

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