雷帕鸣用药指导

Rapamune is an immunosuppressant drug mainly given to organ transplant recipients. It is a bacterial species derived from Streptomyces hygroscopicus. Rapamune is suitable for patients aged 13 or above who have received kidney transplants to prevent organ rejection. Rapamune is recommended for use in combination with cyclosporine and corticosteroids. Monitoring of therapeutic drug plasma concentrations is recommended for all patients receiving Rapamune.

Rapamin should be started as soon as possible after transplantation. For new transplant recipients, the loading dose of Rapamune should be taken for the first time, which is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients.

It should be noted that grapefruit juice can slow down the metabolism of rapamin (sirolimus tablets) regulated by CYP3A4, and therefore cannot be used for administration or dilution of this drug. Use is contraindicated if the patient is allergic to sirolimus, sirolimus derivatives, or any component of rapamin (sirolimus tablets) oral solution. Pregnant and nursing women should not use rapamycin (sirolimus tablets) because it may cause harm to the fetus.

The treatment effect is remarkable, and the successful development of this drug is good news for many patients. However, the price of the original drug Rapamin is relatively high, which is a big burden for patients who need to take the drug for long-term treatment. Many patients choose India's Biocon Repamin. Biocon India, one of India's top three biotech companies, is an emerging global biopharmaceutical company that is committed to reducing the cost of treatment for chronic diseases such as diabetes, cancer and partners to provide affordable healthcare solutions by leveraging India's cost advantages and autoimmune disease patients and healthcare systems around the world.

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