雷帕鸣有效果吗

Is Biocon India effective?

Trial 1 was conducted at 38 research sites in the United States, with 719 patients participating. Randomly assigned after transplantation: 284 patients received rapamycin 2 mg/day, 274 patients received sirolimus 5 mg/day, and 161 patients received azathioprine 2-3 mg/kg/day.

Trial 2 was conducted at 34 research units in Australia, Canada, Europe and the United States, with 576 patients participating. Before transplantation, 227 patients received rapamune 2 mg/day, 219 patients received sirolimus 5 mg/day, and 130 patients received placebo.

In both trials, antilymphocyte antibody induction therapy was contraindicated. In both trials, the primary efficacy endpoint was the rate of treatment failure within the first 6 months after transplantation. Treatment failure was defined as the first episode of acute rejection, graft loss, or death.

Trial analysis results: Compared with azathioprine and placebo, the 2 mg/day and 5 mg/day dosage levels of Rapamune significantly reduced the incidence of treatment failure in the 6 months after transplantation.

Rapamide has remarkable therapeutic effects, and the successful development of this drug is good news for many patients. However, the price of the original drug Rapamin is relatively high, which is a big burden for patients who need to take the drug for long-term treatment. Many patients choose India's Biocon Repamin. Biocon India is one of the three largest biotechnology companies in India and an emerging global biopharmaceutical company.

Sirolimus is recommended for oral administration once daily in combination with cyclosporine and corticosteroids. To reduce differences in the absorption of rapamycin, patients should choose to take it regularly with or without food. Tablets should not be broken or chewed.

Treatment with sirolimus may cause harm to the fetus, so effective contraceptive measures should be taken during treatment with sirolimus and for 12 weeks after stopping. During pregnancy, rapamirumab should be used only if the potential benefits of its use outweigh the potential risks to the embryo/fetus.

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