雷帕鸣怎么用？

It is an effective drug for the treatment of kidney transplantation manufactured by Pfizer of the United States. It is suitable for patients receiving kidney transplantation to prevent organ rejection. Clinical recommendations include the combined use of rapamycin with cyclosporine and corticosteroids. This medicine should be started as soon as possible after transplantation. Rapamin inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies.

In cells, rapamycin binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian Siros BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from G1 to S phase in the cell cycle.

In addition to the original drug Rapamide produced by Pfizer, Rapamide produced by India's Biocon is also popular among patients because of its relatively low price and obvious effects. The use of Rapamide produced by India's Biocon is the same as that of the original drug.

For new transplant recipients, the loading dose of rapamin should be taken for the first time, that is, 3 times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients.

The safety and efficacy of rapamycin in children under 13 years of age have not been established. If used in children under 13 years of age, it is recommended to monitor the whole blood trough concentration of rapamycin. Blind use of medication not only fails to achieve better therapeutic effects, but may also cause harm to the body.

Biocon, a generic drug manufacturer in India, is one of the three largest biotechnology companies in India and an emerging global biopharmaceutical company. If patients want to purchase this version of Rapamin, they can further consult the medical companion service.

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