服用西罗莫司的注意事项

Tablets should only be used by physicians experienced with immunosuppressive therapy and managing kidney transplant patients. Patients should not take medication blindly. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Let’s learn about the precautions for taking Sirolimus from Biocon India.

Anaphylaxis/Hypersensitivity Reactions: Anaphylaxis, angioedema, exfoliative dermatitis, and hypersensitivity vasculitis have been reported.

Malignancy: Increased risk of skin cancer; limit sun and UV exposure; use appropriate sun protection.

Angioedema: An increased risk has been reported with elevated levels of sirolimus or with concomitant use of other drugs known to cause angioedema (such as ACE inhibitors). In some cases, angioedema resolves after stopping the drug or reducing the dose.

Interstitial Lung Disease: Cases (some fatal) of interstitial lung disease (e.g., pneumonia, bronchiolitis obliterans, organizing pneumonia, pulmonary fibrosis, etc.) have been observed; may be associated with pulmonary hypertension (including pulmonary hypertension). ILD can be relieved by reducing the dose or discontinuing treatment.

Hyperlipidemia: May increase blood lipids (cholesterol and triglycerides). Use with caution in patients with hyperlipidemia. Monitor cholesterol/lipids; if hyperlipidemia occurs, follow current management guidelines (diet, exercise, lipid-lowering agents). Antihyperlipidemic treatments may not be effective in achieving normal levels.

Lymphocele/Effusion: Peripheral edema, lymphedema, ascites, and thoracic and pericardial effusions (including severe effusions and cardiac tamponade) have been reported; use sirolimus with caution in patients with poor tolerance to fluid accumulation, such as cardiovascular disease (heart failure or hypertension) and pulmonary disease.

Biocon is one of India's three largest biotech companies and an emerging global biopharmaceutical company that is committed to reducing the cost of treatment for chronic diseases such as diabetes, cancer and autoimmune disease patients by leveraging India's cost advantages and partners to provide affordable healthcare solutions to healthcare systems around the world.

Can be used to improve the condition of lymphoma. Sirolimus blocks signal transduction through different cytokine receptors and blocks the process of T lymphocytes and other cells from the G1 phase to the S phase, thereby exerting an immunosuppressive effect.