西罗莫司在国内买的到吗？

It is a macrolide antibiotic that can be used long-term to help improve disease. Sirolimus blocks signal transduction through different cytokine receptors and blocks the process of T lymphocytes and other cells from the G1 phase to the S phase, thereby exerting an immunosuppressive effect. So, is Biocon India’s sirolimus available in the country?

The original drug sirolimus is produced by Pfizer. Although the original drug has been on the market in China for many years, the price of the original drug is usually relatively high, while the sirolimus produced by India's Biocon is relatively cheap. The current specification of Biocon Sirolimus in India is 1 mg x 10 tablets, and the price is around $200. Patients in need can purchase it abroad, or obtain the drug through domestic professional overseas medical service organizations (such as Medical Companion Travel), and have it delivered directly to their homes, ensuring authenticity.

Biocon is one of India's three largest biotech companies and an emerging global biopharmaceutical company that is committed to reducing the cost of treatment for chronic diseases such as diabetes, cancer and autoimmune disease patients by leveraging India's cost advantages and partners to provide affordable healthcare solutions to healthcare systems around the world.

Sirolimus inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies.

In cells, sirolimus binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

Recommended for use in combination with cyclosporine and corticosteroids, taken orally once daily. To reduce differences in the absorption of sirolimus, patients should choose to take it regularly with or without food. Tablets should not be broken or chewed.