Febuxostat/Febuxib linked to risk of kidney failure

Febuxostat (Febuxostat), as a new xanthine oxidase inhibitor, has been widely used to treat gout andhyperuricemia. It inhibits the activity of xanthine oxidase and reduces uric acid production, thereby effectively controlling hyperuricemia. However, whether febuxostat increases the risk of kidney failure remains an important topic of discussion in the medical community.

Kidney failure usually refers to the inability of the kidneys to effectively perform functions such as excretion, metabolism, and regulating water and electrolyte balance in the body, resulting in the accumulation of toxins in the body. In patients with chronic hyperuricemia, excessive uric acid may cause certain damage to the kidneys, leading to acute or chronic renal failure. Therefore, the use of drugs such as febuxostat to control uric acid levels is crucial for the protection of kidney function. However, existing studies are not entirely consistent as to whether febuxostat directly causes the risk of kidney failure.

Some studies suggest that febuxostat appears to be less protective of renal function than conventional allopurinol. Especially in patients with mild or moderate renal insufficiency, febuxostat can effectively reduce uric acid levels with fewer side effects on the kidneys. In addition, some studies have also found that febuxostat can reduce kidney damage caused by uric acid deposition and help improve kidney health in gout patients.

However, some studies indicate that febuxostat may increase the risk of kidney damage in a small number of high-risk patients, especially those with pre-existing kidney disease or renal failure. Isolated case reports indicate that patients developed signs of kidney damage, including increased serum creatinine levels, during treatment with febuxostat. These results remind us that the patient's renal function status must be carefully considered when treating with febuxostat.

Overall, febuxostat is safe in most patients and does not significantly increase the risk of kidney failure. For patients with existing kidney disease, special caution is required when using this drug. It is recommended to monitor kidney function regularly and adjust drug use according to kidney function if necessary.

Reference materials:https://www.drugs.com