Correct way and time to take Trelagliptin

Trelagliptin (Trelagliptin) is a DPP-4 inhibitor commonly used to treat type 2 diabetes. It helps control blood sugar levels by prolonging the action of insulin. Knowing the correct way and time to take it is crucial to ensure the treatment is effective. This article will introduce the correct use of trolagliptin, recommended dosage, and how to adjust the medication according to different renal function conditions.

First, the usual dose of trolagliptin is 100 mg taken orally once a week for adults. In order to ensure a stable concentration of the drug in the body and maximize its hypoglycemic effect, patients should take the drug on the same day every week. Taking medications regularly and on time can help maintain stable effects of the medication and avoid blood sugar fluctuations.

For patients with renal insufficiency, the dose of trotagliptin needs to be adjusted based on renal clearance (CrCl). For patients with moderate renal impairment (CrCl 30-50 mL/min), the recommended dose is 50 mg once weekly. This dosage adjustment is to reduce the accumulation of the drug in the body and prevent additional burden on the kidneys.

However, trotagliptin is not recommended for patients with severe renal insufficiency (CrCl <30mL/min) or dialysis. For these patients, the excretion capacity of the drug is greatly reduced, and the use of trotagliptin may increase the accumulation of the drug in the body, leading to the risk of adverse reactions. Therefore, in this case, the doctor may recommend other types of antidiabetic drugs or alternative treatment options based on individual circumstances.

When taking trelagliptin, patients should pay attention to taking it on an empty stomach, that is, at least take the medicine 30 minutes before eating. This is because taking the medication on an empty stomach can help it be absorbed more quickly, giving it the best therapeutic effect. If you miss a dose, you should refill the dose as early as possible that day, but it is not recommended to take two doses at the same time the next day to avoid overdose.

Reference materials:https://en.wikipedia.org/wiki/Trelagliptin