Is the injection recommendation of dupilumab/dalbitux worth it?

Dupilumab (dupilumab), as a targeted immunotherapy drug, has demonstrated significant therapeutic effects in a variety of immune diseases, and has been widely used in the treatment of atopic dermatitis, asthma, chronic sinusitis and other diseases. Whether the recommended injection of dupilumab is worth taking requires comprehensive consideration from multiple aspects such as the drug’s efficacy, safety, and patient’s quality of life.

First of all, the injection regimen of dupilumab varies according to the specific conditions of the patient. It is usually administered by subcutaneous injection. The dose and frequency will be adjusted according to the type and severity of the disease. For example, when treating atopic dermatitis, patients are initially treated with a dose of 300 mg every two weeks, whereas when treating asthma or chronic sinusitis, the dose and frequency may be different. The dosing regimen of dupilumab is flexible and can meet the treatment needs of different patients.

From an efficacy perspective, injectable treatment with dupilumab has proven effective in many patients. In patients with atopic dermatitis, it can significantly improve skin lesions, reduce itching, and improve the patient's quality of life. In the treatment of asthma, dupilumab significantly reduces the frequency of exacerbations and reduces patients' dependence on oral steroids by targeting eosinophils. For patients with chronic sinusitis and eosinophilic esophagitis, injection treatment with dupilumab can effectively control the disease and improve the patient's respiratory function and digestive system symptoms.

Secondly, dupilumab has a higher safety profile, especially compared with traditional immunosuppressants, dupilumab has a more targeted mechanism of action and its side effects are usually mild. The most common side effects include injection site reactions, eye inflammation, and allergic reactions. Although these side effects are relatively common, most are mild and can be effectively controlled under the guidance of a doctor.

Reference materials:https://www.dupixent.com/