How long does it take to take Apremilast (Otelor) to see obvious effects?

Apremilast is an oral small molecule phosphodiesterase 4 (PDE4) inhibitor, mainly used for the treatment of moderate to severe plaque psoriasis and psoriatic arthritis. By inhibiting PDE4 activity and increasing intracellular cAMP levels, it regulates the expression of inflammatory factors, reduces the production of pro-inflammatory cytokines, and relieves skin inflammation and joint symptoms. The time for the onset of therapeutic effects varies depending on the severity of the patient's condition, medication compliance and individual differences.

In clinical observation, most patients can show early signs of efficacy after taking the medicine for about 4 weeks. For example, skin itching is reduced, the area of u200bu200bred spots is reduced, and joint pain or swelling is relieved. The efficacy at this stage is usually judged through patient self-report and physician clinical evaluation combined with blood or imaging indicators. Patients with obvious early responses usually tolerate subsequent courses of treatment better and can successfully complete the complete course of treatment.

As treatment continues, the effects are usually more pronounced at 12-16 weeks. Psoriasis patients have significantly reduced erythema and scales, and improved quality of life; psoriatic arthritis patients have experienced increased joint mobility, pain relief, and improved morning stiffness. This stage is an important node to evaluate the effect of treatment. Doctors will combine clinical scores (such as PASI, DLQI or ACR indicators) and imaging examinations to decide whether to continue to maintain the dose or adjust the treatment plan.

Long-term maintenance treatment usually requires 6 months or more to consolidate the efficacy and reduce the risk of recurrence. Skin symptoms, joint function, inflammatory indicators and adverse reactions should be comprehensively evaluated before the treatment course is completed or adjusted. Apremilast is generally well tolerated, but weight, mood, and gastrointestinal reactions still need to be monitored regularly during the course of treatment. Through standardized medication and scientific monitoring, most patients can achieve significant curative effects within 6 months, relieving symptoms and improving quality of life.

Reference materials:https://www.drugs.com/