How much does a box of sirolimus cost?

Sirolimus (sirolimus) is a new macrolide immunosuppressant and anti-tumor agent that belongs to the mammalian target of rapamycin (mTOR) inhibitor class. The mTOR/PI3K pathway has been shown to be involved in vascular development. Activation of mTOR signaling increases the expression of vascular endothelial growth factors A and C (VEGF-A and C), which are key regulators of angiogenesis and lymphangiogenesis respectively, promoting cell growth and vascular proliferation.

Sirolimus can inhibit abnormal vascular proliferation by blocking themTOR/PI3K pathway and reducing the production of VEGF and its receptor responsiveness. The most significant side effects are thrombocytopenia, rash, fatigue, nausea, edema, anorexia, anemia, hyperglycemia, hyperlipidemia, hypertriglyceridemia, increased alkaline phosphatase, increased serum creatinine, lymphopenia, and hypophosphatemia. Rare but potentially serious side effects associated with the use of sirolimus include infections and heart disease.

SirolimusThe original drug has been launched in China and has entered the scope of Class B medical insurance. SpecificationsThe price of each box of 1mg*10 tablets is about 400 yuan. Domestic drugs are only available for patients with anti-rejection reactions in organ transplantation. Patients who do not meet the conditions may not be able to purchase this drug. The reimbursement ratios are different in different regions, and the prices after reimbursement are also different. The original sirolimus drug has also been launched overseas. The price of the Turkish version of Specifications1mg*100 tablets per box is around RMB 2,000 (the price may fluctuate due to exchange rates). The ingredients of the original drugs marketed in China are basically the same as those of foreign original drugs. Currently, there are no generic sirolimus drugs produced in other countries.