Will taking sirolimus increase creatinine?

A major concern with sirolimus is its effect on lipid metabolism. Sirolimus increases total cholesterol, low-density lipoprotein, triglycerides, apoB-100, and apoC-III; these effects are reproducible, dose-dependent, and reversible. Hypercholesterolemia may be due to sirolimus-induced impairment of intracellular cholesterol transport.

Hypertriglyceridemia may be due to decreased lipoprotein lipase activity and increased adipose tissue lipase activity. SRL is associated with increased statin use and increased statin incidence (elevated creatine kinase, abnormal liver function). In a retrospective multivariate analysis of patients treated with sirolimus, cyclosporine A, and prednisone, the main factors contributing to hypercholesterolemia were pretransplant cholesterol levels and exposure to cyclosporine A, sirolimus, and steroids. Dyslipidemia is controllable with medical therapy and is a rare reason for discontinuation; SRL-related hyperlipidemia is not associated with cardiovascular morbidity or mortality even after up to 4 years of treatment.

SirolimusThe original drug has been launched in China and has entered the scope of Class B medical insurance. SpecificationsThe price of each box of 1mg*10 tablets is about 400 yuan. The domestic drug is only available to patients with anti-rejection reactions in organ transplantation. Patients who do not meet the conditions may not be able to purchase this drug. The original sirolimus drug has also been launched overseas. The price of the Turkish version of Specifications1mg*100 tablets per box is around RMB 2,000 (the price may fluctuate due to exchange rates). The ingredients of the original drugs marketed in China are basically the same as those of foreign original drugs. Currently, there are no generic sirolimus drugs produced in other countries.