How long does it take to take sirolimus?

Sirolimus (sirolimus) is an immunosuppressant with antifungal and antitumor effects. In animal models, sirolimus prolonged allograft survival after various organ transplants and reversed acute rejection of cardiac and renal allografts in rats. Oral sirolimus at 2 mg/day and 5 mg/day significantly reduced the incidence of organ rejection in kidney transplant patients with low to moderate immune risk compared with azathioprine or placebo 6 months after transplantation.

In some studies, the immunosuppressive effect of sirolimus persists for up to 6 months after discontinuation of the drug: this tolerance effect is alloantigen specific. Sirolimus can effectively inhibit antigen-induced T cell and B cell proliferation and antibody production. In rodent models of autoimmune diseases, sirolimus inhibited immune-mediated events associated with systemic lupus erythematosus, collagen-induced arthritis, autoimmune type I diabetes, autoimmune myocarditis, experimental allergic encephalomyelitis, graft-versus-host disease, and autoimmune uveoretinitis.

SirolimusThe original drug has been launched in China and has entered the scope of Class B medical insurance. SpecificationsThe price of each box of 1mg*10 tablets is about 400 yuan. The domestic drug is only available to patients with anti-rejection reactions in organ transplantation. Patients who do not meet the conditions may not be able to purchase this drug. The original sirolimus drug has also been launched overseas. The price of the Turkish version of Specifications1mg*100 tablets per box is around RMB 2,000 (the price may fluctuate due to exchange rates). The ingredients of the original drugs marketed in China are basically the same as those of foreign original drugs. Currently, there are no generic sirolimus drugs produced in other countries.