What are the side effects of Selpercatinib?

The most common adverse reactions associated with treatment with Selpercatinib are edema, diarrhea, fatigue, dry mouth, hypertension, abdominal pain, constipation, rash, nausea, and headache. . The most common serious adverse reactions were pneumonia, pleural effusion, abdominal pain, bleeding, anaphylaxis, dyspnea, and hyponatremia. 3% of patients experienced fatal adverse reactions, including sepsis, respiratory failure, hemorrhage, pneumonia, cardiac arrest, sudden death and heart failure.

The most common grade 3 or 4 laboratory abnormalities (≥5%) were lymphopenia, increased alanine aminotransferase (ALT), increased aspartate aminotransferase (AST), decreased sodium, and decreased calcium. Forty-one percent of patients who received serpatinib had dose reductions due to adverse reactions, including increased ALT, increased AST, QT interval prolongation, fatigue, diarrhea, drug allergy, and edema. Adverse reactions that may lead to dose interruption include increased ALT, increased AST, diarrhea, and hypertension. Adverse reactions that may lead to permanent discontinuation include increased ALT, fatigue, sepsis, and increased AST.

The original drug Serpatinib has not yet been launched in China, so it is not covered by medical insurance. Domestic patients cannot yet purchase this drug. Serpatinib marketed overseas The original drug has a US version and a European version. The price of the US version is about 150,000 yuan per box of 80mg*60 pills. The price of the European version of 80mg*56 pills per box is about 21,000 yuan (the price may fluctuate due to the exchange rate), which is expensive. There are also serpatinibgeneric drugs produced abroad. The specification produced by a Bangladesh pharmaceutical factory is 40mg*30 pills per box and the price is about 4,300 yuan (the price may fluctuate due to the exchange rate). The ingredients of the generic drugs are basically the same as those of the original drug.