What are the side effects of Osimertinib?

In an experimental study, 81% of 1,479 patients treated with Osimertinib were exposed for 6 months or longer, and 60% were exposed for more than 1 year. In this pooled safety population, the most common adverse reactions occurring in ≥20% of 1479 patients treated with osimertinib were diarrhea (47%), rash (45%), musculoskeletal pain (36%), nail poisoning (33%), dry skin (32%), stomatitis (26%), fatigue (21%), and cough (20%).

Among 1479 patients treated with osimertinib, the most common laboratory abnormalities were leukopenia (65%), lymphopenia (62%), thrombocytopenia (53%), anemia (47%), and neutropenia (33%). Adverse reactions leading to dose reductions included diarrhea, stomatitis, nail toxicity, and rash, and adverse reactions leading to permanent discontinuation included interstitial lung disease) and rash.

OsimertinibThe original drug has been launched in China and has entered the scope of medical insurance. Its name is Osimertinib Mesylate Tablets. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. SpecificationThe price of 80mg*30 tablets per box is around RMB 5,000, which is relatively expensive. The original drug of Osimertinib has also been launched overseas, and there are also generics of Osimertinib produced in other countries. For example, the price of 80mg*30 tablets per box produced by Bangladesh Yaopin International is around RMB 850 (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of the generic Osimertinib and the original drug are basically the same.