How to take Osimertinib

Doctors will select patients with resectable tumors for adjuvant treatment with Osimertinib (Osimertinib) based on the presence of EGFR exon 19 deletion or EGFR exon 21 L858R mutation in tumor specimens. If these mutations are not detected in plasma specimens, tumor tissue may be detected if feasible. The recommended dose of osimertinib is 80 mg tablets once daily, Treat patients in the adjuvant setting until disease recurrence or unacceptable toxicity or for up to 3 years, and treat patients with metastatic lung cancer until disease progression or unacceptable toxicity.

Osimertinib should be discontinued if serious adverse reactions occur, such as interstitial lung disease(ILD)/pneumonitis, QTc interval prolongation with signs/symptoms of life-threatening arrhythmias, aplastic anemia, great erythema multiforme (EMM), or other allergic reactions. If coadministration with strong CYP3A inducers is unavoidable, increase the dose of osimertinib to 160 mg daily. Three weeks after discontinuing the strong CYP3A4 inducer, 80 mg of osimertinib was resumed.

OsimertinibThe original drug has been launched in China and has entered the scope of medical insurance. Its name is Osimertinib Mesylate Tablets. The reimbursement ratio is different in different regions, and the price after reimbursement may be different. SpecificationThe price of 80mg*30 tablets per box is around RMB 5,000, which is relatively expensive. The original drug of Osimertinib has also been launched overseas, and there are also generics of Osimertinib produced in other countries. For example, the price of 80mg*30 tablets per box produced by Bangladesh Yaopin International is around RMB 850 (the price may fluctuate due to the exchange rate). The price is relatively cheap. The ingredients of the generic Osimertinib and the original drug are basically the same.