Riluzole’s mechanism of action

利鲁唑（Riluzole）是一种用于治疗肌萎缩性侧索硬化（ALS）的谷氨酸拮抗剂，其作用方式未知，药理学特性包括以下内容，其中一些可能与其作用有关：对谷氨酸释放的抑制作用(谷氨酸再摄取的激活)、电压依赖性钠通道的失活以及干扰兴奋性氨基酸受体上的递质结合后的细胞内事件的能力。

当分别以高达20和10mg/kg/天的每日口服剂量给药2年时，利鲁唑在小鼠或大鼠中没有致癌性，这大约等于以mg/m2为基础的推荐人类每日剂量。当雄性和雌性大鼠在交配前和交配期间口服利鲁唑(3、8或15mg/kg ),并在雌性大鼠整个妊娠期和哺乳期持续口服利鲁唑时，高剂量时生育指数降低，胚胎致死率增加。

The original drug Riluzole has been launched in China and has entered the scope of Class B medical insurance. Specifications The price of 50mg*56 tablets per box may be around 4,000 RMB. The price of the Turkish version of Riluzole’s original drug, 50mg*56 tablets, sold overseas may be around RMB 1,200 per box (the price may fluctuate due to exchange rates). There are also generic drugs produced in other countries. The price of a box of 50mg*30 tablets produced by an Indian pharmaceutical factory may be around RMB 1,300 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of generic drugs are basically the same as those of domestic and foreign original drugs. For specific prices and drug information, please consult Yaode Medical Consultants.