Instructions for Riluzole

1. Generic name: Riluzole

Product name:Rilutek

All names: riluzole, Riluzole, RILUTEK

2. Indications:

Riluzole (Riluzole) is indicated for the treatment of amyotrophic lateral sclerosis (ALS).

3. Usage and dosage:

The recommended dose of riluzole is50 mg, taken orally twice daily, and should be taken at least 1 hour before or 2 hours after meals. Serum aminotransferases were measured in patients before and during treatment with riluzole.

4. Adverse reactions:

The most common adverse reactions of riluzole are fatigue, nausea, dizziness, decreased lung function and abdominal pain. The most common adverse reactions that lead to discontinuation of riluzole are nausea, abdominal pain, constipation and elevation of alanine aminotransferase (ALT). Adverse reactions in some cases after marketing include acute hepatitis and jaundice-type toxic hepatitis, renal tubular damage, and pancreatitis.

5. Storage:

Store riluzoleat controlled room temperature between 20°C and 25°C (68°F and 77°F) and away from bright light.

6. Taboo:

Riluzole is contraindicated in patients with a history of severe allergic reaction to Riluzole or any of its components.

7. Mechanism of action:

Riluzole preferentially blocks activity associated with damaged neuronsTTX sensitive sodium channel. Riluzole has also been reported to directly inhibit kainate and NMDA receptors. The drug has also been shown to potentiate GABAA receptors postsynaptically via an allosteric binding site. Since its antiglutamate effect is still detectable in the presence of sodium channel blockers, it is uncertain whether it acts in this manner. Rather its ability to stimulate glutamate uptake appears to mediate many of its effects.

In addition to its effect in accelerating glutamate clearance at synapses, riluzole may also prevent glutamate release from presynaptic terminals.由于CK1δ在TDP-43蛋白病(ALS的病理标志)中起着关键作用，这可能有助于更好地解读药物的作用机制。

8. Overdose:

Overdose symptoms reported after ingestion of 1.5-3 g (30-60 times the recommended dose) of riluzole include acute toxic encephalopathy, coma, somnolence, memory loss, and methemoglobinemia. There is currently no specific antidote for rilutec overdose.

9. Things to note:

Patients should pay attention to the occurrence of adverse events such as liver damage, neutropenia, and interstitial pneumonia during treatment with riluzole.

The original drug Riluzole has been launched in China and has entered the scope of Class B medical insurance. Specifications The price of 50mg*56 tablets per box may be around 4,000 RMB. The price of the Turkish version of Riluzole’s original drug, 50mg*56 tablets, sold overseas may be around RMB 1,200 per box (the price may fluctuate due to exchange rates). There are also generic drugs produced in other countries. The price of a box of 50mg*30 tablets produced by an Indian pharmaceutical factory may be around RMB 1,300 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of generic drugs are basically the same as those of domestic and foreign original drugs. For specific prices and drug information, please consult Yaode Medical Consultants.