Will Pirfenidone rebound after one year of discontinuation?

Pirfenidone (Pirfenidone) is used to treat a lung disease called idiopathic pulmonary fibrosis (IPF). IPF causes scar tissue to form deep in your lungs. Over time, scar tissue thickens and becomes stiff or thick, which can make it harder for your lungs to work. Decreased lung function can make it difficult for you to breathe. When your brain, heart, and other organs don't get enough oxygen, other medical problems can occur.

After discontinuation of pirfenidone, based on current study data, a clear rebound effect following abrupt discontinuation of the drug has not been observed. The main effects of pirfenidone are to slow the progression of the disease and reduce symptoms. For drug treatment of chronic diseases, drug discontinuation requires gradual tapering according to the guidance of a doctor. Abrupt discontinuation of pirfenidone may lead to symptom aggravation or disease progression. However, every patient is different, so whether rebound effects occur after stopping the drug may vary from person to person. Some patients may experience a worsening or worsening of symptoms after stopping the drug, while others may remain stable or improve.

Pirfenidone has been approved for marketing in China under the trade name of Asri. It has entered the scope of Class B medical insurance and is limited to patients with idiopathic pulmonary fibrosis. The specifications produced by domestic pharmaceutical factoriesThe price of 100mg*54 capsules per box is around RMB 500. There are also generic pirfenidone drugs produced in other countries overseas. For example, the price of a box of 200mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 100 (the price may fluctuate due to the exchange rate). The ingredients of the generic drugs are basically the same as those of the original drug. For more drug information and specific prices, please consult Yaode Medical Consultant.