What is the role of intuzumab/oxintuzumab (Besponsa)?

Oxantuzumab/Oxantuzumab (Besponsa) is used to treat acute lymphoblastic leukemia (Acute Lymphoblastic Leukemia, ALL). It is a hematological malignancy that usually involves lymphocytes, a type of white blood cell responsible for the body's immune functions. Olintuzumab/OlintuzumabThe specific mechanism of action is as follows:

1.TargetingCD22antigen: Ogaituzumab/Ointuzumab is a monoclonal antibody drug. Its mechanism of action is by targeting the CD22 antigen on the surface of lymphocytes. CD22 is a protein found on the surface of B cells (a type of lymphocyte). In acute lymphoblastic leukemia, the leukemia cells often express CD22.

2.Inhibit the growth and survival of leukemia cells: Ogaintozumab/Ointozumab binds to CD22 antigen, thus interfering with the normal function of leukemia cells. This includes preventing leukemia cells from growing and dividing, as well as inducing apoptosis (cell death). Through these effects, oxinolizumab helps reduce the number of leukemia cells, thereby alleviating disease symptoms.

3.Treatment of Acute Lymphoblastic Leukemia: Originutuzumab/Oinutuzumab is designed to treat adult B cell acute lymphoblastic leukemia (B-ALL). This type of leukemia usually affects adults and sometimes becomes resistant to traditional treatments or relapses. Therefore,Oplusituzumab/Oplusinutuzumab provides a new treatment option for these patients.

In short, Ogaintozumab/Ointozumab’s main function is to interfere with the growth and survival of acute lymphoblastic leukemia cells by targeting CD22 antigen, thereby reducing the progression of the disease. However, patients should use this drug under the supervision of a doctor, as it may cause some adverse reactions and the treatment plan needs to be individualized based on the patient's specific situation.

Ogaintozumab/Ointozumab has been launched in China, but it is not included in medical insurance. The domestic price is around 60,000 to 70,000 yuan, which is very expensive. Patients can buy it domestically. There are only original drugs available abroad, mainly Pfizer’s original drugs, which cost more than 80,000 yuan.