Is Oplusituzumab/Ointuzumab (Besponsa) a targeted drug?

Olintuzumab/Olintuzumab (Besponsa) is a targeted drug. Targeted drugs are a class of drugs designed to treat specific types of cancer or other diseases by specifically interfering with specific molecules or cells. Ogaintozumab/Ointozumab’s main function is to interfere with the growth and survival of acute lymphoblastic leukemia (ALL) cells by targeting the CD22 antigen on the surface of lymphocytes.

The following is some important information aboutoxinutuzumab/oxinutuzumab as a targeted drug:

1.TargetCD22Antigen: CD22 is a protein located on the surface of B cells, which is found in normal lymphocytes. However, in acute lymphoblastic leukemia, B cells proliferate abnormally and express CD22. Oxantuzumab/Oxantuzumab is designed to bind to the CD22 antigen, thereby selectively affecting leukemia cells without damaging normal cells.

2.Reduced toxicity: Compared with traditional treatments such as radiotherapy and chemotherapy, targeted drugs are generally more selective and therefore can reduce damage to healthy tissue. This helps reduce the risk of adverse effects from treatment and improves patients' quality of life.

3.Effective treatment of acute lymphoblastic leukemia: Ogaintozumab/The targeted nature of Ointozumab makes it an effective drug for the treatment of acute lymphoblastic leukemia. By binding to the CD22 antigen, it prevents the normal function of leukemia cells and interferes with their growth and survival, thereby reducing the number of leukemia cells.

4.Personalized treatment: The use of targeted drugs usually requires individualized treatment based on the patient's specific disease type and molecular characteristics. This helps doctors choose the most appropriate treatment plan based on the patient's specific situation and improves the effectiveness of treatment.

Ogaintozumab/Ointozumab has been launched in China, but it is not included in medical insurance. The domestic price is around 60,000 to 70,000 yuan, which is very expensive. Patients can buy it domestically. There are only original drugs available abroad, mainly Pfizer’s original drugs, which cost more than 80,000 yuan.