Should Delamanid be taken before or after meals?

After a single oral dose of 100mg Delamanid , the peak plasma concentration is 135ng/mL and reaches steady-state concentration after 10-14 days. Plasma exposure to delamanid increases disproportionately with increasing doses. In animal models (dog, rat, mouse), the oral bioavailability of delamanid has been reported to be 35%-60%, and the absolute oral bioavailability in humans is estimated to be between 25% and 47%.

It is recommended to take delamanid with food as food facilitates better absorption compared to first-line anti-tuberculosis drugs which should be taken on an empty stomach. Following oral administration, maximum concentrations are observed at 4-5 hours. The half-life after discontinuation of medication is 38 hours. In early trials, delamanid exposure was not found to be dose-proportional and it plateaued at 300 mg. This may be due to the poor water solubility of the drug and limited absorption at high doses. When administered with a standard meal, human oral bioavailability is increased approximately 2.7-fold compared to fasted conditions because delamanid exhibits poor water solubility.

The original drug Delamani has been launched in China and is included in the scope of Class B medical insurance. Reimbursement is limited to patients with multi-drug-resistant tuberculosis. Specifications The price of each box of 50mg*60 tablets may be around RMB 6,000. The price of the Russian version of the original drug Dramani, 50mg*48 tablets, sold overseas may be around RMB 1,000-2,000 per box (the price may fluctuate due to the exchange rate). There is currently no generic version of Dramani available on the market. For more drug information and specific prices, please consult Yaode’s medical consultant.