What are the side effects of Vorinostat?

Vorinostat toxicity has been observed at doses above 400 mg daily, rendering dose escalation of minimal clinical benefit. Using doses approved by the U.S. Food and Drug Administration (FDA), the most common drug-related adverse reactions can be divided into 4 syndromes: Gastrointestinal symptoms (diarrhea, nausea, anorexia, weight loss, vomiting, constipation), systemic symptoms (fatigue, chills), hematological abnormalities (thrombocytopenia, anemia) and taste disorders (dysgeusia, dry mouth).

These side effects of treatment with vorinostat are generally mild to moderate and do not require intervention or non-invasive intervention. Other life-threatening side effects that require hospitalization include thrombocytopenia, dehydration, pulmonary embolism, squamous cell carcinoma, and severe anemia. QTc interval prolongation has also been reported in some patients taking vorinostat. Therefore, it is recommended that patients taking antiarrhythmic drugs undergo regular screening while taking vorinostat. Vorinostat is a pregnancy category D drug. An animal study found that vorinostat crosses the placenta and may harm the developing fetus. The most common developmental defects are low birth weight and incomplete ossification of the skull, vertebrae, and other bones of the axial skeleton.

The original drug of vorinostat is not currently on the market in China, and therefore cannot be included in the national medical insurance coverage. Overseas, there is an American version of the original drug, specifications100mg*120 pills per box, which may cost around 100,000 yuan (the price may fluctuate due to exchange rate effects). It is very expensive, and there is currently no generic version of vorinostat produced and launched. For more drug information and specific prices, please consult a medical consultant.