What are the side effects of Trifluridine and Tipiracil Tablets (Lonsurf)?

In clinical studies of patients receiving trifluridine tipiracil tablets (Lonsurf) as monotherapy, the most common adverse reactions or laboratory abnormalities (≥10%) were neutropenia, anemia, thrombocytopenia, fatigue, nausea, decreased appetite, diarrhea, vomiting, abdominal pain, and pyrexia. In clinical studies of patients treated with trifluridine and bevacizumab, the most common adverse reactions or laboratory abnormalities (≥20%) were neutropenia, anemia, thrombocytopenia, fatigue, nausea, increased aspartate aminotransferase (AST), increased alanine aminotransferase (ALT), increased alkaline phosphatase, decreased sodium, diarrhea, abdominal pain, and decreased appetite. The combination of trifluridine and tipiracil has caused fetal harm in pregnant animals and has not been tested on pregnant women. Therefore, pregnant women should not take it, and women cannot become pregnant while taking it.

The original drug of trifluridinetipiracil tablets has been marketed in China under the trade name Langsif, but it has not yet entered the scope of medical insurance. The price per box may be around RMB 6,000, and the price per box of the Hong Kong version may be more than RMB 10,000 (the price may fluctuate due to exchange rates). The Japanese version of trifluridine tipiracil tablets sold overseas may cost around more than 5,000 yuan per box (the price may fluctuate due to exchange rates). There are also cheaper generic versions of trifluridine and tipiracil tablets available overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of each box produced by an Indian pharmaceutical factory may be around more than 1,000 yuan (the price may fluctuate due to exchange rates).