How to take Trifluridine Tipiracil Tablets (Lonsurf)

Lonsurf is administered orally as a tablet to patients twice daily with food on days 1-5 and 8-12 of each 28-day cycle, as a single agent or in combination with bevacizumab at a recommended dose of 35 mg/m2 up to a maximum of 80 mg per dose (based on trifluridine composition) until disease progression or unacceptable toxicity. Round dosage to the nearest 5 mg increment.

The doctor will obtain a complete blood cell count before and on the 15th day of each cycle when the patient takes the drug; if discomfort occurs, the dose can be adjusted under the guidance of the doctor, and a maximum of 3 dose reductions are allowed. Patients who cannot tolerate the oral dose of 20 mg/m2 twice daily should permanently discontinue trifluridine tipiracil tablets. Do not increase your dose after reducing it. The 28-day cycle of trifluridine and tipiracil may be repeated, depending on how well the drug works for the patient and the side effects they experience. Patients should take trifluridine and tipiracil tablets strictly according to the instructions and do not take more or less than the number of times prescribed by the doctor.

The original drug of trifluridinetipiracil tablets has been marketed in China under the trade name Langsif, but it has not yet entered the scope of medical insurance. The price per box may be around RMB 6,000, and the price per box of the Hong Kong version may be more than RMB 10,000 (the price may fluctuate due to exchange rates).

The Japanese version of the original trifluridine tipiracil tablets marketed overseas may cost around more than 5,000 yuan per box (the price may fluctuate due to exchange rates). There are also cheaper generic versions of trifluridine and tipiracil tablets available overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of each box produced by an Indian pharmaceutical factory may be around more than 1,000 yuan (the price may fluctuate due to exchange rates).