Treatment of drug resistance to trifluridine and tipiracil tablets (Lonsurf)

Lonsurf (Lonsurf) is a drug that treats cancer by slowing the growth and spread of cancer cells. It can be used to treat adults with colon or rectal cancer. It is also used to treat stomach cancer. This treatment is used when the cancer has spread to other parts of the body, or when other treatments have not worked.

Resistance refers to the reduction or failure of a certain drug in the treatment of a specific disease. If drug resistance occurs while taking trifluridine tipiracil tablets, you should consult a doctor in time to inform the patient of the drug resistance. The doctor may recommend relevant examinations to evaluate the cause of drug resistance and formulate follow-up treatment plans based on the specific situation. For example, other chemotherapy drugs, targeted drugs, or immunotherapy may be selected to obtain better therapeutic effects. If conventional treatments don't work, doctors may consider enrolling the patient in a clinical trial to try new treatments or medications.

The original drug of trifluridinetipiracil tablets has been marketed in China under the trade name Langsif, but it has not yet entered the scope of medical insurance. The price per box may be around RMB 6,000, and the price per box of the Hong Kong version may be more than RMB 10,000 (the price may fluctuate due to exchange rates). The Japanese version of trifluridine tipiracil tablets sold overseas may cost around more than 5,000 yuan per box (the price may fluctuate due to exchange rates). There are also cheaper generic versions of trifluridine and tipiracil tablets available overseas. Their pharmaceutical ingredients are basically the same as those of the original drugs sold domestically and abroad. For example, the price of each box produced by an Indian pharmaceutical factory may be around more than 1,000 yuan (the price may fluctuate due to exchange rates).