Duvelisib capsules (Duvelisib) Chinese instructions

1. Indications:

Duvelisel is used to treat certain types of lymphoma, including adult Tcell leukemia lymphoma/lymphoma cell leukemia (ATLL/CTCL) and relapsed small Bcell lymphoma. These diseases are usually related to abnormalities in the PI3K signaling pathway. Duveliside can interfere with this pathway, thereby slowing or inhibiting the growth of tumor cells.

2. Mechanism of action:

Duveliced is a PI3K inhibitor that interferes with the growth and spread of cancer cells by inhibiting multiple isoforms of the PI3K signaling pathway, including the delta type and the γ type. PI3KThe signaling pathway plays an important role in biological processes such as cell growth, differentiation, survival and metabolism. Duveliced’s multi-target mechanism of action makes it an effective targeted drug

3. Pharmacology:

The pharmacological characteristics of duvelised include inhibition of thePI3K signaling pathway and interference with a variety of leukemia and lymphoma cells. It slows down or inhibits the growth of cancer cells by regulating intracellular signaling pathways. Duvelised has anticancer activity against a variety of cell types, including T cells and B cells.

4. Dosage and usage:

1.Duvelisel is usually taken in the form of oral capsules.

2.The dosage and usage should be based on the patient's specific condition and the doctor's recommendations.

3.Patients should abide by the doctor's prescription and medication instructions and should not change the dosage or stop medication on their own.

5. Side effects:

Duvelisel may cause a series of side effects, including but not limited to:

1.Infections, including upper respiratory tract infections and urinary tract infections.

2.Nausea and vomiting.

3.Diarrhea.

4.Itchy skin, rash and dry skin.

5.Fatigue.

6.Pneumonia.

7.Liver damage.

8.Intestinal inflammation.

9.High blood pressure.

10.Pulmonary arterial hypertension (PAH).

11.Autoimmune diseases.

Patients should promptly inform their physician of any side effects or discomfort symptoms so that the discomfort can be effectively managed and alleviated.

6. Warnings and precautions:

1.Patients require regular medical monitoring, including laboratory tests, while taking duvelisel.

2.Duveliced may cause infection, so patients should take precautions and avoid contact with sources of infection.

3.Because duvelised may have adverse effects on the liver and intestines, patients need to regularly check liver function and intestinal inflammation.

4.Patients should pay close attention to symptoms of cardiovascular problems such as high blood pressure and PAH and notify their doctor promptly.

5.Duveliced may cause autoimmune diseases, and patients need to be alert to symptoms related to autoimmunity.

7. Contraindications:

1.Patients who are allergic to duvelised or any ingredient in the drug.

2.Patients with severe infections, such as active tuberculosis.

8. Drug interactions:

Duveliced may interact with other drugs, including increasing or decreasing the concentrations of other drugs, so patients should use other drugs concurrently under the supervision of a physician.

9. Medication for special groups:

1.Pregnant women, lactating women, and women planning pregnancy should avoid the use of duveliside because of its possible adverse effects on the embryo.

2.The safety and effectiveness of duvliside in children have not been established.

The original drug of Duvelisel Capsules has been launched in China, but it is not covered by medical insurance. Patients can buy it domestically at a price of more than 20,000 yuan. For specific prices, please consult the local hospital pharmacy.

The above is the Chinese instructions for Duvelisel Capsules. Patients should follow the doctor's recommendations and prescriptions when using this drug, and receive regular medical monitoring to ensure the safety and effectiveness of the treatment. In addition, patients should pay close attention to any discomfort or unusual symptoms and contact their doctor promptly to obtain appropriate treatment and support.