No increase in platelet count after taking Avatrombopag for 5 days

The effectiveness of avatrombopag may vary from person to person. Typically, it may take some time before you see the effects of increasing your platelet count after taking avatrombopag. If the patient has been taking avatrombopag for 5 consecutive days but still does not see signs of increased platelet count, it is recommended to contact the doctor immediately to evaluate the condition and treatment response, and make appropriate adjustments as needed. Also follow your doctor's instructions and take your medicine on time.

Following single dose administration, avatropopag is detectable in plasma 0.5-1 hour after dosing and maximum concentrations are observed approximately 4-6 hours after dosing. In multiple-dose studies, avatropopag was detectable in plasma 0.25–1 hour after the first and repeated doses, with maximum concentrations observed approximately 4.5–6 hours after the first (day 1) and final (day 14) doses. In multiple-dose studies, avatropopag produced a small increase in platelet counts at the 3 mg/day dose, but no statistically significant increase in platelet counts was seen before the 10 and 20 mg doses compared with placebo.

The original drug of avatrombopag has been launched in China and has entered the scope of Class B medical insurance, but it is only reimbursed for eligible patients. The price of a common 20mg*15 tablets may be more than 7,000 yuan per box, while the original drug of avatrombopag marketed overseas is even more expensive. It is understood that there are generic drugs of avatrombopag available overseas, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of a box of 20mg*30 tablets in Laos pharmaceutical production specifications may be around RMB 1,000 (the price may fluctuate due to exchange rates).