How long does it take for Avatrombopag to be effective?

It takes about 10 to 13 days for patients to take Avatrombopag to treat their disease, which causes platelet levels to rise. For patients with chronic liver disease who are scheduled to have surgery, avatropopag should be started 10 to 13 days before the planned surgery. The duration of this course of treatment is 5 u200bu200bdays, and the procedure should be performed 5 to 8 days after the last dose. However, the effect may need to be judged based on the patient's tolerance response to the drug.

Avatrombopag increases blood levels of platelets by telling the body to make more megakaryocytes to make platelets. Avatrombopag is a platelet stimulant. The production of platelets in the body begins with hematopoietic stem cells, which develop into megakaryocytes, which produce platelets. Avatrombopag (a thrombopoietin receptor agonist) tells the body to make more HSCs develop into megakaryocytes. Once there are more megakaryocytes, the number of platelets that can be made increases, causing platelet levels to rise. But low levels of platelets in the blood (thrombocytopenia) can increase the risk of bleeding, bruising, blood in the urine or bowel movements, fatigue, enlarged spleen, and heavy menstrual bleeding. If you have a procedure or surgery, there is a risk of severe bleeding or bruising.

The original drug of avatrombopag has been launched in China and has entered the scope of Class B medical insurance, but it is only reimbursed for eligible patients. The price of a common 20mg*15 tablets may be more than 7,000 yuan per box, while the original drug of avatrombopag marketed overseas is even more expensive. It is understood that there are generic drugs of avatrombopag available overseas, and their pharmaceutical ingredients are basically the same as those of the original drug. For example, the price of a box of 20mg*30 tablets in Laos pharmaceutical production specifications may be around RMB 1,000 (the price may fluctuate due to exchange rates).