Is taking 12 pills of Pirfenidone a day effective?

Pirfenidone (Pirfenidone) is available in capsules containing 267 mg of pirfenidone and, more recently, as bioequivalent tablets containing 267, 534 or 801 mg of pirfenidone. Both agents treat idiopathic pulmonary fibrosis (IPF), with pirfenidone generally reducing the rate of forced vital capacity decline in patients with mild to moderate idiopathic pulmonary fibrosis, while prolonging progression-free survival and reducing the risk of idiopathic pulmonary fibrosis-related and all-cause mortality.

Pirfenidone is a white to light yellow, non-hygroscopic crystalline powder that is slightly soluble in water and easily soluble in ethanol (96%). It is available in tablets and capsules. Each common pirfenidone capsule contains 267 mg of pirfenidone as the active ingredient. The advent of pirfenidone tablets has reduced the daily pill burden of pirfenidone because the recommended divided daily maintenance dose of 2403 mg/day can be administered as one 801 mg tablet three times daily instead of three 267 mg capsules three times daily. Therefore, the patient's daily dose of 12 pirfenidone pills was too high and did not meet the recommended dosage.

The original drug pirfenidone has been approved for marketing in China and has entered the scope of Class B medical insurance. Reimbursement is limited to patients who meet the indications. SpecificationsThe price of each box of 100mg*54 tablets is about 500 yuan. There are also generic pirfenidone drugs produced in other countries overseas. For example, the price of a box of 200mg*30 tablets produced by an Indian pharmaceutical factory is around RMB 100 (the price may fluctuate due to the exchange rate). The ingredients of the generic drugs are basically the same as those of the original drug. For more drug information and specific prices, please consult Yaode Medical Consultant.