How effective is MITOTANE?

MITOTANE was approved by the U.S. Food and Drug Administration (FDA) in 1970 for the treatment of inoperable, functional and non-functional adrenocortical carcinoma, adrenocortical hyperplasia and tumor-induced hypercortisolism. 1989 Mitotane was approved for marketing in Hong Kong, China.

How effective is mitotane?

Some trials have shown that it is effective for adrenocortical cancer that cannot be surgically removed or has distant metastasis. The objective effective rate is 34% to 61%, and the median remission period is 6 to 7 months. For functional adrenocortical cancer, it can alleviate the symptoms of cortical hyperfunction, shrink tumors, and prolong life.

About 40% of oral administration is absorbed from the gastrointestinal tract, and the remaining 60% is excreted in the feces as unchanged form. 5~10g per day, the blood concentration can reach 10~90ug/ml, and the metabolite concentration 30~50g. After stopping the drug for 6~9ug/ml weeks, ortho-chlorane can still be detected in the plasma. Mitotane is highly fat-soluble and is mainly stored in fat. Water-soluble metabolites excreted in urine account for approximately 25% of the drug dose. Mitotane(Mitotane)is an oral adrenal cell agent. The chemical name is ()-1, 1-dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane(also known as o, p′-DDD). Mitotane is a white granular solid composed of transparent colorless crystals. It is odorless and has a slightly pleasant aromatic smell. It is soluble in ethanol and has a molecular weight of 320.05. The inactive ingredients in mitotane are:Microcrystalline cellulose, polyethylene glycol3350, silicon dioxide and starch.

There are generic drugs that are officially on the market in Laos. The retail price is about 500mg100 tablets3 about one thousand. If you want to get more high-quality information, you can contact Yaode. Yade will do its best to learn more about high-quality overseas drugs for you.