What are the side effects of taking MITOTANE?

MITOTANEIs an oral drug indicated for the treatment of inoperable functional and non-functional adrenocortical carcinomas. Instructions for Mitotane The initial dose is 2g to 6g orally daily, taken in three or four divided doses. Gradually increase the dose until the blood concentration reaches 14 to 20 mg/L, or to a tolerable level.

The incidence of mitotane side effects >10% is nausea (39%), vomiting (37%), drowsiness/drowsiness (25 %), Anorexia(24%), Dizziness(15%), Skin Rash(15%), Diarrhea(13%), etc. Blurred vision, diplopia, lens opacification, toxic retinopathy, hematuria, hemorrhagic cystitis and proteinuria, hypertension, orthostatic hypotension and flushing, general pain and hyperthermia, reduced protein-bound iodine, etc. may also occur.

Mitotan is an adrenal cytotoxic agent with an unknown mechanism of action. Mitotane alters the peripheral metabolism of steroids and directly inhibits the adrenocortex. A decrease in 17-hydroxycorticosteroids and an increase in the formation of 6-beta-hydroxycortisol have been reported in the absence of a decrease in corticosteroid concentrations. Mitotane is a white granular solid composed of transparent colorless crystals. It is odorless and has a slightly pleasant aromatic smell. It is soluble in ethanol and has a molecular weight of 320.05. The inactive ingredients in mitotaneare:microcrystalline cellulose, polyethylene glycol3350, silica, and starch.

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