What should you do if you experience adverse reactions while taking mitotane?

Mitotane is the only adrenergic drug approved by the Food and Drug Administration for the treatment of adrenocortical cancer (ACC). This drug has a cytotoxic effect on tumor tissue, inducing cell death and an anti-secretory effect on adrenal cells by inhibiting the synthesis of adrenocortical steroids, which are related to the pathogenesis of ACC.

Mitotane is used to treat inoperable functional or non-functioning adrenocortical carcinoma. High doses of mitotane are usually required to achieve therapeutic plasma concentrations, which may result in some side effects. What should you do if an adverse reaction occurs?

If adverse reactions occur, you can refer to the following suggestions:

1.Gastrointestinal reactions

Based on clinical treatment experience, patients treated with mitotane often experience gastrointestinal symptoms, such as nausea, diarrhea, and anorexia. For gastrointestinal symptoms, 5-serotonin blockers can be used for treatment, and patients should be instructed to eat small and frequent meals, eat a light diet, observe the time and severity of nausea and vomiting, and inform the doctor in time if necessary.

2.Dizziness

Neurological symptoms are also common, including drowsiness, ataxia, dizziness, confusion, etc. If the above symptoms occur, the patient should be instructed to rest in bed, reduce activities, and reduce external interference. If serious adverse reactions occur, you should inform your doctor immediately and follow the doctor's advice to reduce the dosage or stop taking the drug.

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