What is the recurrence rate after treatment with Bedaquilin?

Bedaquiline (Bedaquiline) is a new type of anti-tuberculosis drug. Bedaquiline and delamanid are the first new drugs registered for the treatment of tuberculosis in 40 years. They have significant effects in the treatment of pulmonary tuberculosis. Bedaquiline can improve the cure rate and reduce the risk of recurrence. Bedaquiline selectively inhibits bacterial ATP synthase and reduces ATP production.

The recommended dosage of bedaquiline is 400 mg once a day for 2 weeks, and then 200 mg 3 times a week. mg for 22 weeks (a total of 24weeks). The incidence of hepatic adverse reactions was higher in adult and pediatric patients receiving antituberculosis regimens containing bedaquiline than in patients receiving antituberculosis regimens that did not contain bedaquiline. Monitor liver function tests(Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, bilirubin) at baseline, monthly during treatment, and as needed. In addition, symptoms of abnormal liver function tests (such as fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly) should be monitored at baseline, monthly during treatment, and as needed. If new or worsening signs or symptoms of hepatic dysfunction occur(e.g., serum aminotransferases and/ or clinically important elevation of bilirubin, fatigue, anorexia, nausea, jaundice, dark urine, liver tenderness, hepatomegaly), please test for viral hepatitis and discontinue other hepatotoxic drugs. If the elevated transaminase concentration is accompanied by a total bilirubin concentration > 2 timesULN, a transaminase concentration > 8 timesULN, or a transaminase concentration > If 5ULN persists for more than 2 weeks, stop using bedaquiline. Avoid the use of other hepatotoxic drugs or herbal products, especially in patients with impaired hepatic function.

The Russian version is the same as that of domestic imported drug manufacturers. The price in Russian hospitals is around 100mg188 tablets1 around 10,000 to 50,000. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.