What is the cure rate for Bedaquilin?

Mycobacterium tuberculosis causes a contagious lung disease with high mortality in developing countries. Bedaquiline (Bedaquiline) selectively inhibits bacterial ATP synthase and reduces ATP production. It has a significant effect in the treatment of tuberculosis. Bedaquiline is developed and produced by Johnson & Johnson Pharmaceuticals in the United States. It is used to treat extensive drug resistance(XDR)TB Drug-resistant Mycobacterium tuberculosis causes )or treatment-intolerant or unresponsive MDRpulmonary tuberculosis.

Relevant tests have shown that the cure rate of bedaquiline is about 80% and the typical treatment time is 6 months. Bedaquiline is primarily metabolized by CYP3A4. Does not inhibitCYP1A2, 2A6, 2C8/9/10, pan>2C19, 2D6, 2E1, 3A4< /span>, 3A4/5 or 4A do not induceCYP1A to any clinically important degree 2, 2C9, 2C19 or 3A4. Moderate and Potent CYP3A4Inducers: Pharmacokinetic interactions(bedaquiline AUCdecreased, therapeutic efficacy may be reduced), avoid concurrent use. PotentCYP3A4inhibitors: pharmacokinetic interactions(bedaquiline AUC increased, the risk of adverse reactions may increase), avoid continuous 14If used together for more than 7 days, monitor for side effects unless the benefits of concurrent use outweigh the risks. After oral administration, peak plasma concentrations are reached approximately 5 hours. Peak plasma concentrations and AUC increase proportionally with daily single doses up to 700 mg and multiple daily doses up to 400 mg.

The Russian version is the same as that of domestic imported drug manufacturers. The price in Russian hospitals is around 100mg188 tablets1 around 10,000 to 50,000. If you want to get more high-quality information, you can contact Yaode, and Yaode will do its best to help you learn more about high-quality overseas drugs.