Latest medical news: the most dangerous adverse reactions of bedaquiline

Bedaquiline (Bedaquiline) is a diarylquinoline antibiotic that has been approved in many countries for use in combination with other antibiotics in patients with multidrug-resistant tuberculosis. The most commonly reported side effects are headache, nausea, joint pain, and lung infection. Active tuberculosis is a serious and sometimes fatal bacterial infection. Multidrug-resistant strains are associated with higher mortality. A warning in the prescribing guidelines for bedaquiline includes increased mortality and QT interval prolongation.

In a placebo-controlled trial in adults, bedaquiline treatment was associated with an increased risk of death compared with placebo treatment. When effective treatment options are not available, it can only be used on patients 5 years old and above. Bedaquiline can cause QT interval prolongation. Concomitant use with drugs that prolong the QT interval may result in additive QT prolongation. Monitor electrocardiogram. Discontinue bedaquiline if severe ventricular arrhythmias occur or QTcF interval prolongation exceeds 500 ms.

The drug is sold in China under the name of daquiline fumarate tablets and has been included in the scope of medical insurance. The price of a common specification of 100mg*24 tablets per box may be around 10,000 yuan, which is relatively expensive. The price of the Russian version of Bedaquiline sold overseas, Specifications100mg*188 tablets per box, may be around RMB 15,000 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of Bedaquiline sold domestically and abroad are basically the same. Currently, there are no generic bedaquiline drugs produced and marketed overseas. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.