What disease is bedaquiline fumarate used to treat?

Bedaquiline (Bedaquiline) is a commonly used diarylquinoline antimycobacterial drug that can be used to treat multidrug-resistant tuberculosis in adults. It inhibits ATP synthase during the cell wall synthesis of Mycobacterium tuberculosis, thereby interfering with the energy metabolism of the bacteria and inhibiting its growth and reproduction. This drug can be used only when no other effective treatment options are available, and it should be used under the guidance of a doctor. The dosage and method of use should be adjusted according to individual conditions, and should not be used blindly on your own.

World Health Organization (WHO) guidelines recommend the inclusion of bedaquiline in treatment regimens for extensively drug-resistant (XDR) tuberculosis (TB) due to its drug resistance pattern and its unique mechanism of action. While results from clinical trials suggest bedaquiline is beneficial, it also carries a risk of adverse effects, some of which may be life-threatening. Before initiating bedaquiline, a baseline examination is required to determine the relative risk to the patient of known adverse drug reactions. When using bedaquiline, ECG monitoring is essential.If the patient is asymptomatic, weekly follow-up ECGs are recommended untilQTc values u200bu200bare normal.

The drug is sold in China under the name of daquiline fumarate tablets and has been included in the scope of medical insurance. The price of a common specification of 100mg*24 tablets per box may be around 10,000 yuan, which is relatively expensive. The price of the Russian version of Bedaquiline sold overseas, Specifications100mg*188 tablets per box, may be around RMB 15,000 (the price may fluctuate due to the exchange rate). The pharmaceutical ingredients of Bedaquiline sold domestically and abroad are basically the same. Currently, there are no generic bedaquiline drugs produced and marketed overseas. For specific prices and drug information of overseas drugs, please consult Yaode Medical Consultant.